If you want more information, you can read a rather lengthy post directly from Adobe on how to optimize Photoshop that mirrors what I said, as well as adds more in-depth coverage on the topics.

Here are a few things that have helped me improve performance in Photoshop CS5 (though they’ll most likely work just fine in versions CS3 and CS4 as well).

Memory

Go into Photoshop’s preferences (Command + K) and select the Performance item from the source list on the left. The first thing to adjust is the Memory Usage. I generally keep the RAM set between 60-70% with the slider. This allows me to use a good amount of my RAM for Photoshop, but still leave enough for other apps and the System itself. However, if you have less than 4GB of RAM, you should probably stick to 50% max. Your mileage may vary.

Memory use and cache settings improves performance

History & Cache

The next thing to adjust is your History & Cache settings. You can use the preset buttons (hover over them for a brief description of which you should use). Only my laptop, I use the settings you see in the screenshot above. Because I tend to use my laptop for web or other low-resolution work, the settings have worked superbly.

3D VRAM

If you’re running Photoshop CS5 Extended, you can also check the 3D preferences and up the VRAM (video RAM) use to the max amount. I don’t do any 3D work, so I can’t tell you how well this works or not, but I keep it set to the max anyway.

Layers Panel

If you work with a lot of layers in your Photoshop document, you can reduce the size of the individual icon layer thumbnails. The smaller the icon, the less memory Photoshop needs to redraw those thumbnails every time you make a change to a layer. Just make a quick trip to the Layers panel flyout menu and choose the Panel Options… menu item. You can also turn those layer thumbnails off completely if you’re really organized with layer naming.

The Rest

There are numerous other tips that can help speed up Photoshop. Limiting the number of fonts installed and active is huge. You can also limit the number of files Photoshop remembers in the File menu list (adjust in the Photoshop preferences). Keep the layer count down as much as possible goes a long way, and not using Photoshop’s built-in Navigation panel with its giant thumbnail is a great idea as well.